Have tried several meds for depression in the past three years and have changed recently from serequel to invega. I am also on 80mg/day of prozac and have been feeling worse and worse. My depression keeps worsening and my anger and agitation is getting very bad. I don't know what to do anymore. I am tired of going back to my dr and phcyciatrist and trying new meds that don't seem to work anymore. I am started to get scared that my anger is going to explode one day at work or somewhere in this crazy place called society. I don't find anything interesting anymore and everyday is a struggle. Have been to numerous councellors and programs for anger managment,read cbt books,and nothing seems to work anymore. I don't want things to get too far and I hurt somebody or worse. I have a history of substance abuse with drugs in the past but the last few years it has only been alcohol. Someone please help!!!!!!